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. 2018 Aug 14;53(5):1967–1979. doi: 10.3892/ijo.2018.4523

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Copyright: © Chiu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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3-MA treatment suppresses CPT-induced accumulation of autophagic markers in H1299 cells. (A) White arrows indicate GFP-LC3 puncta in H1299 cells following treatment with various concentrations of 3-MA, in the presence of 0.5 µM CPT. Magnification, ×200. (B) GFP-LC3 puncta/cell was observed under a microscope and counted. Data are presented as the means ± standard deviation. ^#P<0.05 vs. the control group; ^*P<0.001 vs. the control group; ^&P<0.001 vs. the CPT-treated group. 3-MA, 3-methyladenine; CPT, camptothecin; GFP, green fluorescent protein; LC3, microtubule-associated proteins 1A/1B light chain 3.