Table I.
Characteristics of subjects with MI and control individuals.
| Characteristic | Control | Myocardial infarction | P-value |
|---|---|---|---|
| Subjects (n) | 5,774 | 1,152 | |
| Age (years) | 50.6±10.2 | 55.6±7.4 | <0.0001 |
| Sex (men/women, %) | 52.1/47.9 | 85.4/14.6 | <0.0001 |
| Smoking (%) | 42.5 | 46.7 | 0.0105 |
| Obesity (%) | 31.0 | 42.7 | <0.0001 |
| Body mass index (kg/m2) | 23.2±3.5 | 24.6±3.5 | <0.0001 |
| Hypertension (%) | 31.7 | 68.9 | <0.0001 |
| Systolic BP (mmHg) | 121±18 | 139±26 | <0.0001 |
| Diastolic BP (mmHg) | 75±13 | 78±16 | <0.0001 |
| Diabetes mellitus (%) | 12.7 | 61.3 | <0.0001 |
| Fasting plasma glucose (mmol/l) | 5.66±1.78 | 7.66±3.39 | <0.0001 |
| Blood hemoglobin A1c (%) | 5.72±0.96 | 6.88±1.70 | <0.0001 |
| Dyslipidemia (%) | 56.9 | 84.9 | <0.0001 |
| Serum triglycerides (mmol/l) | 1.32±0.98 | 1.77±1.25 | <0.0001 |
| Serum HDL-cholesterol (mmol/l) | 1.65±0.45 | 1.17±0.34 | <0.0001 |
| Serum LDL-cholesterol (mmol/l) | 3.18±0.83 | 3.15±0.98 | 0.8593 |
| Chronic kidney disease (%) | 10.3 | 29.1 | <0.0001 |
| Serum creatinine (µmol/l) | 69.8±61.0 | 91.9±98.1 | <0.0001 |
| eGFR (ml min−1 1.73 m−2) | 78.7±17.1 | 71.2±27.8 | <0.0001 |
| Hyperuricemia (%) | 15.2 | 25.6 | <0.0001 |
| Serum uric acid (µmol/l) | 321±89 | 356±105 | <0.0001 |
Quantitative data are presented as the mean ± standard deviation and were compared between subjects with MI and controls using the unpaired t-test. Categorical data were compared between the two groups with Pearson's χ2 test. Based on Bonferroni's correction, P<0.0025 (0.05/20) was considered statistically significant. Obesity was defined as a body mass index of ≥25 kg/m2; hypertension as a systolic BP of ≥140 mmHg, diastolic BP of ≥90 mmHg, or the taking of anti-hypertensive medication; diabetes mellitus as a fasting plasma glucose level of ≥6.93 mmol/l, blood hemoglobin A1c content of ≥6.5%, or the taking of antidiabetic medication; dyslipidemia as a serum triglyceride concentration of ≥1.65 mmol/l, serum HDL-cholesterol <1.04 mmol/l, serum LDL-cholesterol ≥3.64 mmol/l, or the taking of anti-dyslipidemic medication; chronic kidney disease as an eGFR of <60 ml min−1 1.73 m−2; and hyperuricemia as a serum uric acid concentration of >416 µmol/l or the taking of uric acid-lowering medication. MI, myocardial infarction; BP, blood pressure; HDL, high density lipoprotein; LDL, low density lipoprotein; eGFR, estimated glomerular filtration rate.