Table IV.

25 SNPs significantly (P<1.60×10⁻⁶) associated with myocardial infarction in the exome-wide association study.

Gene	SNP	Nucleotide substitutiona	Amino acid substitution	Chromosome	Position	MAF (%)	Allele OR	P-value (allele frequency)
PLCB2	rs200787930	C/T	E1106K	15	40289298	1.2	0.01	8.81×10−26
CXCL8	rs188378669	G/T	E31*	4	73741568	1.2	0.01	1.33×10−25
MARCH1	rs61734696	G/T	Q137K	4	164197303	1.2	0.01	1.50×10−25
VPS33B	rs199921354	C/T	R80Q	15	91013841	1.2	0.01	2.07×10−25
TMOD4	rs115287176	G/A	R277W	1	151170961	1.2	0.01	9.03×10−25
COL6A3	rs146092501	C/T	E1386K	2	237371861	1.2	0.02	1.27×10−24
ZNF77	rs146879198	G/A	R340*	19	2934109	1.2	0.02	1.27×10−24
ADGRL3	rs192210727	G/T	R580I	4	61909615	1.3	0.07	1.12×10−20
ALDH2	rs671	G/A	E504K	12	111803962	27.6	1.54	2.67×10−19
ACAD10	rs11066015	G/A		12	111730205	27.5	0.65	3.35×10−19
BRAP	rs3782886	A/G		12	111672685	29.3	1.49	5.52×10−17
HECTD4	rs11066280	T/A		12	112379979	29.0	1.49	6.48×10−17
HECTD4	rs2074356	C/T		12	112207597	25.4	1.48	4.24×10−15
OR52E4	rs11823828	T/G	F227L	11	5884973	36.6	1.43	1.86×10−12
	rs12229654	T/G		12	110976657	22.5	1.39	1.45×10−10
NAA25	rs12231744	C/T	R876K	12	112039251	35.1	0.74	1.07×10−9
ATXN2	rs7969300	T/C	N248S	12	111555908	38.8	0.76	8.46×10−9
GOSR2	rs1052586	T/C		17	46941097	48.7	0.78	1.80×10−7
TCHP	rs74416240	G/A		12	109904793	13.3	1.37	2.47×10−7
GIT2	rs925368	A/G	N389S	12	109953174	12.5	1.37	4.41×10−7
	rs2523644	A/G		6	31374707	8.1	1.49	4.75×10−7
OAS3	rs2072134	C/T		12	112971371	17.6	1.33	5.28×10−7
CCDC63	rs10774610	T/C		12	110902439	23.7	1.30	5.42×10−7
	rs2596548	G/T		6	31362769	5.4	1.60	6.01×10−7
CCDC63	rs10849915	T/C		12	110895818	23.6	1.28	7.71×10−7

Allele frequencies were analyzed using Fisher's exact test.

^aMajor allele/minor allele. SNP, single nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio.