Table IX.
Association between SNPs and chronic kidney disease as determined by multivariable logistic regression analysis.
| Gene | SNP | Dominant
|
Recessive
|
Additive 1
|
Additive 2
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | |||
| COL6A5 | rs200982668 | G/A | 0.0002 | 0.25 | 0.12-0.52 | 0.0002 | 0.25 | 0.12-0.52 | ||||||
| MARCH1 | rs61734696 | G/T | 0.0004 | 0.26 | 0.12-0.55 | 0.0004 | 0.26 | 0.12-0.55 | ||||||
| MUC17 | rs78010183 | A/T | 0.0008 | 0.35 | 0.19-0.65 | 0.0008 | 0.35 | 0.19-0.65 | ||||||
| MOB3C | rs139537100 | C/T | 0.0006 | 0.27 | 0.13-0.57 | 0.0006 | 0.27 | 0.13-0.57 | ||||||
| PLCB2 | rs200787930 | C/T | 0.0007 | 0.27 | 0.13-0.57 | 0.0007 | 0.27 | 0.13-0.57 | ||||||
| CXCL8 | rs188378669 | G/T | 0.0004 | 0.26 | 0.12-0.55 | 0.0004 | 0.26 | 0.12-0.55 | ||||||
| VPS33B | rs199921354 | C/T | 0.0007 | 0.27 | 0.13-0.58 | 0.0007 | 0.27 | 0.13-0.58 | ||||||
| TMOD4 | rs115287176 | G/A | 0.0007 | 0.27 | 0.13-0.58 | 0.0007 | 0.27 | 0.13-0.58 | ||||||
| ADGRL3 | rs192210727 | G/T | 0.0006 | 0.27 | 0.12-0.57 | 0.4876 | 0.0007 | 0.27 | 0.13-0.57 | 0.9964 | ||||
| ZNF77 | rs146879198 | G/A | 0.0009 | 0.28 | 0.13-0.59 | 0.0009 | 0.28 | 0.13-0.59 | ||||||
| COL6A3 | rs146092501 | C/T | 0.0010 | 0.28 | 0.13-0.60 | 0.0010 | 0.28 | 0.13-0.60 | ||||||
Multivariable logistic regression analysis was performed with adjustment for age, sex, and the prevalence of hypertension and diabetes mellitus. Based on Bonferroni's correction, P<0.0011 (0.05/44) was considered statistically significant. SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.