Table VI.

11 SNPs significantly (P<1.59×10⁻⁶) associated with chronic kidney disease in the exome-wide association study.

Gene	SNP	Nucleotide substitutiona	Amino acid substitution	Chromosome	Position	MAF (%)	Allele OR	P-value (allele frequency)
COL6A5	rs200982668	G/A	E2501K	3	130470894	1.3	0.21	5.08×10−9
MARCH1	rs61734696	G/T	Q137K	4	164197303	1.2	0.22	1.97×10−8
MUC17	rs78010183	A/T	T1305S	7	101035329	1.8	0.29	2.04×10−8
MOB3C	rs139537100	C/T	R24Q	1	46615006	1.2	0.23	4.91×10−8
PLCB2	rs200787930	C/T	E1106K	15	40289298	1.2	0.23	4.94×10−8
CXCL8	rs188378669	G/T	E31*	4	73741568	1.2	0.23	7.83×10−8
VPS33B	rs199921354	C/T	R80Q	15	91013841	1.2	0.23	7.86×10−8
TMOD4	rs115287176	G/A	R277W	1	151170961	1.2	0.23	1.25×10−7
ADGRL3	rs192210727	G/T	R580I	4	61909615	1.3	0.25	1.88×10−7
ZNF77	rs146879198	G/A	R340*	19	2934109	1.2	0.24	2.95×10−7
COL6A3	rs146092501	C/T	E1386K	2	237371861	1.2	0.24	2.99×10−7

Allele frequencies were analyzed using Fisher's exact test.

^aMajor allele/minor allele. SNP, single nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio.