Table VII.
Association between SNPs and myocardial infarction as determined by multivariable logistic regression analysis.
| Gene | SNP | Dominant
|
Recessive
|
Additive 1
|
Additive 2
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | P-value | OR | 95% CI | |||
| PLCB2 | rs200787930 | C/T | <0.0001 | 0.01 | 0.01-0.10 | <0.0001 | 0.01 | 0.01-0.10 | ||||||
| CXCL8 | rs188378669 | G/T | <0.0001 | 0.01 | 0.01-0.10 | <0.0001 | 0.01 | 0.01-0.10 | ||||||
| MARCH1 | rs61734696 | G/T | <0.0001 | 0.01 | 0.01-0.10 | <0.0001 | 0.01 | 0.01-0.10 | ||||||
| VPS33B | rs199921354 | C/T | <0.0001 | 0.01 | 0.01-0.10 | <0.0001 | 0.01 | 0.01-0.10 | ||||||
| TMOD4 | rs115287176 | G/A | <0.0001 | 0.01 | 0.01-0.11 | <0.0001 | 0.01 | 0.01-0.11 | ||||||
| COL6A3 | rs146092501 | C/T | <0.0001 | 0.01 | 0.01-0.10 | <0.0001 | 0.01 | 0.01-0.10 | ||||||
| ZNF77 | rs146879198 | G/A | <0.0001 | 0.01 | 0.01-0.11 | <0.0001 | 0.01 | 0.01-0.11 | ||||||
| ADGRL3 | rs192210727 | G/T | <0.0001 | 0.06 | 0.02-0.16 | 0.1736 | <0.0001 | 0.06 | 0.02-0.16 | 0.9960 | ||||
| ALDH2 | rs671 | G/A | <0.0001 | 2.00 | 1.56-2.55 | <0.0001 | 2.00 | 1.70-2.36 | 0.0040 | 1.46 | 1.13-1.90 | <0.0001 | 2.71 | 2.08-3.53 |
| ACAD10 | rs11066015 | G/A | <0.0001 | 0.51 | 0.39-0.65 | <0.0001 | 0.50 | 0.43-0.59 | 0.0049 | 0.69 | 0.53-0.89 | <0.0001 | 0.37 | 0.29-0.49 |
| BRAP | rs3782886 | A/G | <0.0001 | 1.98 | 1.67-2.34 | <0.0001 | 1.88 | 1.48-2.39 | <0.0001 | 1.84 | 1.55-2.20 | <0.0001 | 2.58 | 1.99-3.35 |
| HECTD4 | rs11066280 | T/A | <0.0001 | 2.02 | 1.71-2.38 | <0.0001 | 1.92 | 1.51-2.45 | <0.0001 | 1.88 | 1.58-2.24 | <0.0001 | 2.66 | 2.05-3.46 |
| HECTD4 | rs2074356 | C/T | <0.0001 | 1.85 | 1.57-2.17 | <0.0001 | 1.92 | 1.47-2.51 | <0.0001 | 1.73 | 1.46-2.06 | <0.0001 | 2.48 | 1.87-3.28 |
| OR52E4 | rs11823828 | T/G | <0.0001 | 1.56 | 1.30-1.87 | <0.0001 | 2.16 | 1.74-2.68 | 0.0152 | 1.28 | 1.05-1.56 | <0.0001 | 2.46 | 1.93-3.13 |
| rs12229654 | T/G | <0.0001 | 1.64 | 1.39-1.92 | <0.0001 | 1.89 | 1.41-2.53 | <0.0001 | 1.54 | 1.30-1.82 | <0.0001 | 2.27 | 1.67-3.07 | |
| NAA25 | rs12231744 | C/T | <0.0001 | 0.60 | 0.51-0.71 | <0.0001 | 0.49 | 0.37-0.64 | <0.0001 | 0.67 | 0.56-0.79 | <0.0001 | 0.40 | 0.30-0.53 |
| ATXN2 | rs7969300 | T/C | <0.0001 | 0.59 | 0.50-0.70 | <0.0001 | 0.55 | 0.43-0.71 | <0.0001 | 0.65 | 0.55-0.77 | <0.0001 | 0.44 | 0.34-0.57 |
| GOSR2 | rs1052586 | T/C | 0.0002 | 0.71 | 0.59-0.85 | <0.0001 | 0.61 | 0.50-0.75 | 0.0236 | 0.80 | 0.66-0.97 | <0.0001 | 0.53 | 0.42-0.67 |
| TCHP | rs74416240 | G/A | <0.0001 | 1.46 | 1.23-1.73 | 0.2849 | <0.0001 | 1.46 | 1.22-1.74 | 0.1399 | ||||
| GIT2 | rs925368 | A/G | <0.0001 | 1.48 | 1.24-1.76 | 0.5500 | <0.0001 | 1.49 | 1.25-1.79 | 0.3309 | ||||
| rs2523644 | A/G | <0.0001 | 1.74 | 1.41-2.14 | 0.5858 | <0.0001 | 1.76 | 1.42-2.17 | 0.4407 | |||||
| OAS3 | rs2072134 | C/T | <0.0001 | 1.45 | 1.23-1.71 | 0.0408 | 1.51 | 1.02-2.25 | <0.0001 | 1.42 | 1.20-1.69 | 0.0093 | 1.71 | 1.14-2.55 |
| CCDC63 | rs10774610 | T/C | <0.0001 | 1.38 | 1.18-1.62 | 0.0085 | 1.49 | 1.11-2.01 | 0.0009 | 1.33 | 1.12-1.58 | 0.0009 | 1.68 | 1.24-2.29 |
| rs2596548 | G/T | <0.0001 | 1.95 | 1.53-2.48 | 0.3820 | <0.0001 | 2.04 | 1.60-2.61 | 0.4739 | |||||
| CCDC63 | rs10849915 | T/C | <0.0001 | 1.38 | 1.18-1.63 | 0.0184 | 1.44 | 1.06-1.94 | 0.0006 | 1.34 | 1.14-1.59 | 0.0021 | 1.63 | 1.19-2.22 |
Multivariable logistic regression analysis was performed with adjustment for age, sex, and the prevalence of hypertension, diabetes mellitus, and dyslipidemia. Based on Bonferroni's correction, P<0.0005 (0.05/100) was considered statistically significant. SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.