Table XIII.
Association between genes, chromosomal loci, and SNPs associated with MI in the present study and previously examined cardiovascular disease-related phenotypes.
| Gene/chr. locus | SNP | Chr. | Position | Previously examined phenotypes |
|---|---|---|---|---|
| TMOD4 | rs115287176 | 1 | 151170961 | None |
| COL6A3 | rs146092501 | 2 | 237371861 | None |
| ADGRL3 | rs192210727 | 4 | 61909615 | None |
| CXCL8 | rs188378669 | 4 | 73741568 | Total cholesterol (23063622) |
| MARCH1 | rs61734696 | 4 | 164197303 | Adiponectin concentrations (20887962) |
| 6p21.3 | rs2596548 | 6 | 31362769 | MI (21971053) |
| rs2523644 | 31374707 | |||
| OR52E4 | rs11823828 | 11 | 5884973 | None |
| TCHP | rs74416240 | 12 | 109904793 | None |
| GIT2 | rs925368 | 12 | 109953174 | None |
| CCDC63 | rs10849915 | 12 | 110895818 | None |
| rs10774610 | 110902439 | |||
| 12q24.1 | rs12229654 | 12 | 110976657 | HDL-cholesterol (21909109) |
| ATXN2 | rs7969300 | 12 | 111555908 | MI (19820697, 19198610), CAD (19820697, 23202125, 21060863) |
| BRAP | rs3782886 | 12 | 111672685 | MI (21971053, 19820697, 21107343), CAD (21971053, 21572416, 23202125, 19820697, 23364394, 21060863) |
| ACAD10 | rs11066015 | 12 | 111730205 | CAD (23364394, 23202125) |
| ALDH2 | rs671 | 12 | 111803962 | MI (21971053), CAD (21971053, 21572416, 23202125) |
| NAA25 | rs12231744 | 12 | 112039251 | MI (19820697, 23202125), CAD (21971053, 19820697) |
| HECTD4 | rs2074356 | 12 | 112207597 | MI (19820697), CAD (21971053, 21572416, 22751097, 19820697, 23364394, 23202125) |
| rs11066280 | 112379979 | |||
| OAS3 | rs2072134 | 12 | 112971371 | HDL-cholesterol (21909109) |
| PLCB2 | rs200787930 | 15 | 40289298 | Triglycerides (23063622) |
| VPS33B | rs199921354 | 15 | 91013841 | Type 2 diabetes (22885922) |
| GOSR2 | rs1052586 | 17 | 46941097 | Systolic BP (21909110, 21909115) |
| ZNF77 | rs146879198 | 19 | 2934109 | None |
Data were obtained from the Genome-Wide Repository of Associations Between SNPs and Phenotypes Search database (https://grasp.nhlbi.nih.gov/Search.aspx) with P<1.0×10−6. Numbers in parentheses are PubMed IDs. SNP, single nucleotide polymorphism; MI, myocardial infarction; Chr., chromosome; HDL, high density lipoprotein; CAD, coronary artery disease; BP, blood pressure.