Table XVI.
Gene Ontology analysis of the 18 genes identified in the present study.
| Gene | Function | Biological process |
|---|---|---|
| MOB3C | Protein binding, metal ion binding | Uncharacterized |
| TMOD4 | Actin binding, tropomyosin binding | Muscle contraction, actin filament organization, myofibril assembly, pointed-end actin filament capping |
| COL6A3 | Serine-type endopeptidase inhibitor activity, extracellular matrix structural constituent conferring tensile strength, collagen-containing extracellular matrix | Cell adhesion, muscle organ development, negative regulation of endopeptidase activity, extracellular matrix organization |
| ADGRL3 | G protein-coupled receptor activity, calcium ion binding, protein binding, carbohydrate binding | Neuron migration, signal transduction, G protein-coupled receptor signaling pathway, positive regulation of synapse assembly, cell-cell adhesion via plasma-membrane adhesion molecules |
| CXCL8 | Cytokine activity, interleukin-8 receptor binding, protein binding | Positive regulation of angiogenesis, induction of positive chemotaxis, defense response, inflammatory response, immune response, cell cycle arrest, negative regulation of G protein-coupled receptor protein signaling pathway, negative regulation of cell proliferation, cytokine-mediated signaling pathway, calcium-mediated signaling, regulation of cell adhesion, positive regulation of neutrophil chemotaxis, receptor internalization, response to endoplasmic reticulum stress, intracellular signal transduction, PKR-like endoplasmic reticulum kinase-mediated unfolded protein response, neutrophil activation, cellular responses to fibroblast growth factor stimulus, lipopolysaccharide, interleukin-1, and tumor necrosis factor |
| MARCH1 | Ubiquitin-protein transferase activity, zinc ion binding, MHC protein binding, ubiquitin protein ligase activity | Protein polyubiquitination, immune response, antigen processing and presentation of peptide antigen via MHC class II |
| OR52E4 | G protein-coupled receptor activity, olfactory receptor activity | Signal transduction, G protein-coupled receptor signaling pathway, sensory perception of smell, response to stimulus, detection of chemical stimulus involved in sensory perception of smell |
| TCHP | Protein binding | Apoptotic process, negative regulation of cell growth, negative regulation of cilium assembly |
| GIT2 | GTPase activator, kinase activity, metal ion binding | Phosphorylation, positive regulation of GTPase activity |
| CCDC63 | Cell differentiation | Spermatogenesis, spermatid development, cilium movement, outer dynein arm assembly |
| OAS3 | Nucleotide binding, 2′-5′-oligoadenylate synthetase activity, RNA binding, protein binding, ATP binding, nucleotidyltransferase activity, metal ion binding | Immune response, nucleobase-containing compound metabolic process, defense response to virus, negative regulation of viral genome replication, interferon-g-mediated signaling pathway, regulation of ribonuclease activity |
| PLCB2 | Phosphatidylinositol phospholipase C activity, calcium ion binding, phosphoric diester hydrolase activity | Phospholipid metabolic process, intracellular signal transduction, G protein-coupled receptor signaling pathway, activation of phospholipase C activity, Wnt signaling pathway, calcium-modulating pathway, inositol phosphate metabolic process |
| VPS33B | Protein binding, AP-3 adaptor complex, clathrin complex | Vesicle docking involved in exocytosis, endosome organization, protein transport, vesicle-mediated transport, peptidyllysine hydroxylation, melanosome localization, lysosome localization, collagen metabolic process, membrane fusion, platelet a granule organization |
| ZNF77 | RNA polymerase II transcription factor activity, sequence-specific DNA binding, metal ion binding | Regulation of DNA-templated transcription, regulation of transcription by RNA polymerase II |
| COL6A5 | Collagen-containing extracellular matrix, protein binding, extracellular matrix structural constituent conferring tensile strength | Cell adhesion |
| NFKBIL1 | Protein binding | Inhibitor of NF-κB kinase/NF-κB signaling, cytoplasmic sequestering of transcription factor, negative regulation of lipopolysaccharide-mediated signaling pathway, NF-κB transcription factor activity, tumor necrosis factor production, Toll-like receptor signaling pathway |
| NCR3 | Signaling receptor binding, protein binding, protein homodimerization activity, cell adhesion molecule binding | Regulation of immune response, homophilic and heterophilic cell-cell adhesion via plasma-membrane adhesion molecules, cell recognition, positive regulation of natural killer cell-mediated cytotoxicity, susceptibility to natural killer cell-mediated cytotoxicity and T cell-mediated cytotoxicity |
| MUC17 | Protein binding, PDZ domain binding, extracellular matrix constituent, lubricant activity | Stimulatory C-type lectin receptor signaling pathway, O-glycan processing, cellular homeostasis |
Data for predicted functions and biological processes for the genes were obtained from the database of Gene Ontology and GO Annotations (QuickGO; https://www.ebi.ac.uk/QuickGO). GO, Gene Ontology; MHC, major histocompatibility complex; NF-κB, nuclear factor-κB.