Figure 1.

Outline of DF- and IT-specific pattern identification. Motif and PPI data were integrated with gene expression data using the PANDA algorithm, to generate TF-target regulation networks for the different subtypes of GC. Differentially expressed genes were subsequently mapped to these networks, and DF-and IT-specific patterns were identified. DF, diffuse; GC, gastric cancer; IT, intestinal; PANDA, Passing Attributes between Networks for Data Assimilation; PPI, protein-protein interaction; TF, transcription factor.