Table I.
Expression of HOXA11 in LUAD based on the The Cancer Genome Atlas database.
| Clinicopathological feature | N (%) | HOXA11 expression (log2) | T- or F-value | P-value |
|---|---|---|---|---|
| Tissue type | ||||
| Normal | 22 (6.8) | 1.41±0.937 | T=3.239 | 0.001 |
| LUAD | 302 (93.2) | 3.15±2.506 | ||
| Age (years) | ||||
| <60 | 96 (31.8) | 3.12±2.644 | T=−0.140 | 0.888 |
| ≥60 | 206 (68.2) | 3.16±2.446 | ||
| Sex | ||||
| Male | 138 (45.7) | 3.20±2.558 | T=0.318 | 0.750 |
| Female | 164 (54.3) | 3.11±2.469 | ||
| Ethnicity | ||||
| Caucasian | 226 (87.9) | 3.06±2.526 | F=0.212 | 0.809 |
| Black | 26 (10.1) | 3.29±2.270 | ||
| Asian | 5 (1.9) | 2.55±1.461 | ||
| Tumor stage | ||||
| T1/T2 | 255 (85.0) | 3.13±2.507 | T=−0.422 | 0.673 |
| T3/T4 | 45 (15.0) | 3.30±2.561 | ||
| N stage | ||||
| NX | 7 (2.3) | 1.65±0.992 | F=8.111 | <0.001 |
| N0/N1 | 243 (80.5) | 2.94±2.456 | ||
| N2/N3 | 52 (17.2) | 4.32±2.537 | ||
| M stage | ||||
| MX | 81 (27.0) | 3.12±2.449 | F=0.142 | 0.867 |
| M0 | 202 (67.3) | 3.12±2.532 | ||
| M1 | 17 (5.7) | 3.45±2.655 | ||
| Clinical stage | ||||
| I/II | 177 (59.0) | 2.89±2.395 | T=−2.127 | 0.034 |
| III/IV | 123 (41.0) | 3.53±2.648 | ||
| Survival status | ||||
| Dead | 121 (40.1) | 3.48±2.683 | T=1.827 | 0.069 |
| Alive | 181 (59.9) | 2.93±2.363 | ||
| Recurrence | ||||
| Distant metastasis | 53 (58.2) | 3.15±2.559 | F=1.362 | 0.261 |
| Loco-regional recurrence | 35 (38.5) | 2.61±2.526 | ||
| New primary tumor | 3 (3.3) | 0.97±1.053 |
Values are expressed as the mean ± standard deviation. LUAD, lung adenocarcinoma; N, Number; SD, standard deviation; T, Student's t-test; F, one-way analysis of variance; TNM, tumor-nodes-metastasis; HOXA11, homeobox A11.