Table IV.

Correlations between expression of ARHGEF7 in CRC tissues and clinicopathologic variables of patients with CRC in the training cohort.

Clinicopathologic variable	n	ARHGEF7 expression		P-value
		Low (n=72)	High (n=108)
Sex
Female	75	35	40	0.123
Male	105	37	68
Age (years)
≤60	89	38	51	0.465
>60	91	34	57
CEA (ng/ml)
≤5	110	49	61	0.119
>5	70	23	47
Tumor differentiation
I/II	83	43	40	0.003
III/IV	97	29	68
Tumor site
Colon	78	31	47	0.951
Rectum	102	41	61
Tumor size
≤5 cm	94	40	54	0.465
>5 cm	86	32	54
pT stage
T1/T2	56	33	23	0.001
T3/T4	124	39	85
pN stage
N0	85	47	38	<0.001
N+	95	25	70
Lymphatic/microvascular/nerve invasion
Negative	81	42	39	0.003
Positive	99	30	69
Mesenteric tumor deposit formation
Negative	114	54	60	0.008
Positive	66	18	48
Distant metastasis
Negative	98	51	47	<0.001
Positive	82	21	61

CRC, colorectal cancer; CEA, carcinoembryonic antigen; ARHGEF7, Rho guanine nucleotide exchange factor 7.