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. 2018 Aug 27;42(5):2343–2352. doi: 10.3892/ijmm.2018.3842

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ISL1 decreases cisplatin sensitivity of TNBC cells. (A) Compared with the vehicle group, treatment with 10 μM cisplatin induced a significant cell growth arrest, which was partially reversed by ISL1 overexpression and augmented by ISL1 silencing in MDA-MB-231 cells. (B) Compared with the vehicle group, treatment with 10 μM cisplatin induced a significant cell growth arrest, which was partially reversed by ISL1 overexpression and augmented by ISL1 silencing in MDA-MB-468 cells. (C) Compared with the vehicle group, significant cell apoptosis was induced by 10 μM cisplatin treatment, which was reversed by ISL1 overexpression and augmented by ISL1 silencing in MDA-MB-231 cells. (D) Compared with the vehicle group, significant cell apoptosis was induced by 10 μM cisplatin treatment, which was reversed by ISL1 overexpression and augmented by ISL1 silencing in MDA-MB-468 cells. ^*P<0.05, ^**P<0.01 and ^***P<0.0001. siRNA, small interfering RNA; ISL1, Islet 1; OD, optical density; PI, propidium iodide.