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. 2018 Sep 6;42(5):2665–2675. doi: 10.3892/ijmm.2018.3861

Figure 1.

Figure 1

Melanogenesis. Obtained from Niu and Aisa (9). TYR, tyrosinase; TRP-1, tyrosinase-related protein 1; TRP-2, tyrosinase-related protein 2; MITF, microphthalmia-associated transcription factor; MAPK, mitogen-activated protein kinase; P38, p38 MAPK; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; cAMP, intracellular cyclic adenosine monophosphate; Dvl, Dishevelled; Go/Gq, G protein; GSK-3β, glycogen synthase kinase 3β; CRE, cAMP-response element; CREB, cAMP-response element binding protein; CBP, CREB binding protein; TCF-LEF, T cell factor-lymphoid enhancer factor; PKA, protein kinase A; α-MSH, α melanocyte stimulating hormone; PI3K, phosphoinositide 3-kinase; Akt, protein kinase B; NO, nitric oxide; MC1R, melanocortin 1 receptor; SCF, stem cell factor; AC, adenylyl cyclase; c-Kit, proto-oncogene c-Kit.