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. 2018 Aug 8;42(5):2584–2594. doi: 10.3892/ijmm.2018.3813

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Immunofluorescence analysis revealed the variations in cleaved-caspase-3 and αB-crystallin expression. Following treatment with 300 μmol/l t-BH for 3 and 6 h, the levels of cleaved-caspase-3 were significantly enhanced. DHA was found to restrain this change, whereas fluoxetine was able to neutralize the function of DHA. Variations were slightly different for αB-crystallin: Oxidative stress raised the levels of αB-crystallin after 3-h treatment with 300 μmol/l t-BH, while causing αB-crystallin reduction in the 6-h group. Furthermore, pretreatment with DHA increased the αB-crystallin levels, whereas fluoxetine depressed the expression of αB-crystallin (scale bar, 10 μm). t-BH, tert-butyl hydroperoxide; DHA, docosahexaenoic acid.