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. 2018 Sep 4;53(5):1953–1966. doi: 10.3892/ijo.2018.4552

Figure 2.

Figure 2

MDA-MB-231 cells exhibit increased caspase-1 activity and IL-1β secretion after TNF-α and ATP treatment, which is enhanced in RT-R-MDA-MB-231 cells. (A and B) MDA-MB-231 and RT-R-MDA-MB-231 cells were treated with TNF-α or ATP with the indicated dose and times, and (A) caspase-1 activity and (B) IL-1β secretion levels were then measured as described in the Materials and methods. The values represent the means ± SEM of 3 independent experiments. *P<0.05 and **P<0.01, compared to the control (CTRL) of MDA-MB-231 cells; ##P<0.01, compared to the CTRL of RT-R-MDA-MB-231 cells; §§P<0.01, comparison between MDA-MB-231 and RT-R-MDA-MB-231 cells at each time point. ATP, adenosine triphosphate; RT-R, radiotherapy-resistant; IL-1β, interleukin-1β; TNF-α, tumor necrosis factor-α.