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. 2018 Aug 27;42(5):2628–2640. doi: 10.3892/ijmm.2018.3844

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Copyright: © Lin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Schematic presentation of the study protocol. Pigs were randomly divided into 3 groups: Sham, Model and SM-DOO (n=6). The SM-DOO group received SM (1 g/kg/day) and DOO (0.1 ml/kg/day) orally for 8 weeks. At 4 weeks, an ameroid constrictor was placed around the left anterior descending coronary artery in the Model and SM-DOO groups. At weeks 2, 4 and 8, biochemical markers, myocardial marker enzymes and blood gas constituents were measured in the serum. After 8 weeks, echocardiography, X-ray coronary angiography and hemodynamic analysis were performed. Myocardial tissue underwent morphological, histopathological, apoptosis and western blot analysis to evaluate the cardioprotective effects and underlying mechanisms of SM-DOO. SM, Radix Salvia miltiorrhiza; DOO, Lignum Dalbergia odorifera volatile oil; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling.