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The ketogenic diet (KD) fails to increase catalase in mice without PPARγ2. Twoweek treatment with a KD increases hippocampal catalase mRNA and protein in (A) epileptic Kcna1−/− mice (n = 3/group) and (B) wildtype Pparγ+/+ mice (n = 3–4/group); however, catalase mRNA and protein did not change with KD treatment of (C) Pparγ−/− mice (n = 3/group). Significance determined by an unpaired t-test, *p<0.05, ***p<0.001.
