Table 1.
Prognostic factors for distant metastasis-free interval
| Variable | Univariate |
Multivariate |
||
|---|---|---|---|---|
| 10-Year rate (%) | p-value | HR (95% CI) | p-value | |
| Age (yr) | ||||
| < 45 | 88.1 | 0.002 | 1 | |
| ≥ 45 | 94.4 | 0.60 (0.39-0.99) | 0.049 | |
| Menopausal, status | ||||
| Premenopausal | 91.2 | 0.141 | ||
| Perimenopausal or postmenopausal | 94.1 | |||
| Molecular subtype | ||||
| Luminal A | 96.8 | < 0.001 | 1 | |
| Luminal B | 91.1 | 2.25 (1.06-4.77) | 0.034 | |
| HER2 | 86.5 | 4.50 (1.78-11.40) | 0.001 | |
| Triple negative | 88.9 | 5.13 (2.20-11.95) | < 0.001 | |
| T category | ||||
| T1 | 98.1 | < 0.001 | 1 | |
| T2-3 | 86.8 | 2.27 (1.12-4.58) | 0.023 | |
| T4 | 76.3 | 3.68 (1.37-9.87) | 0.010 | |
| N category | ||||
| N0 | 98.0 | < 0.001 | 1 | |
| N1 | 92.0 | 3.44 (1.04-11.37) | 0.043 | |
| N2-3 | 77.7 | 6.98 (2.06-23.62) | 0.002 | |
| Histologic grade | ||||
| I-II | 92.7 | < 0.001 | 1 | |
| III | 90.4 | 0.76 (0.43-1.32) | 0.329 | |
| Lymphovascular invasion | ||||
| No | 96.0 | < 0.001 | 1 | |
| Yes | 86.9 | 1.23 (0.71-2.14) | 0.466 | |
| Primary surgery | ||||
| Breast-conserving | 96.3 | < 0.001 | 1 | |
| Mastectomy | 77.5 | 1.21 (0.41-3.59) | 0.733 | |
| Lymph node surgery | ||||
| No ALND | 97.8 | < 0.001 | 1 | |
| ALND | 86.1 | 1.05 (0.36-3.09) | 0.933 | |
| Chemotherapy | ||||
| No | 98.8 | < 0.001 | 1 | |
| Yes | 90.5 | 0.83 (0.23-2.99) | 0.778 | |
HR, hazard ratio; CI, confidence interval; HER2, human epidermal growth factor receptor 2; ALND, axillary lymph node dissection.