Table 1.
Univariate and multivariate analyses of clinicopathologic factors for overall survival
| Factor | No. | Median survival (mo) | HR (95% CI) | Univariate p-value | Multivariate p-value |
|---|---|---|---|---|---|
| Sex | |||||
| Male | 21 | 22 | - | 0.444 | - |
| Female | 75 | 27 | |||
| Age (yr) | |||||
| < 60 | 61 | 28 | - | 0.242 | - |
| ≥ 60 | 35 | 25 | |||
| Bismuth type | |||||
| I/II | 18/15 | 33/32 | - | 0.188 | - |
| III/IV | 33/30 | 27/24 | |||
| Biliary drainages | |||||
| Yes | 86 | 36 | - | 0.140 | - |
| No | 10 | 32 | |||
| CA 19-9 (U/mL) | |||||
| < 37 | 29 | 36 | 3.437 | 0.022 | 0.064 |
| ≥ 37 | 67 | 22 | |||
| Operation time (min) | |||||
| < 500 | 46 | 26 | - | 0.340 | - |
| ≥ 500 | 50 | 26 | |||
| Transfusion | |||||
| Yes | 27 | 26 | - | 0.087 | - |
| No | 69 | 36 | |||
| Cell differentiation (well/moderate/poor) | 33/39/24 | 32/39/21 | - | 0.114 | - |
| Tumor size (cm) | |||||
| < 4 | 40 | 30 | - | 0.105 | - |
| ≥ 4 | 51 | 26 | |||
| Perineural invasion | |||||
| Yes | 25 | 25 | - | 0.394 | - |
| No | 71 | 28 | |||
| Lymphatic invasion | |||||
| Yes | 30 | 25 | - | 0.180 | - |
| No | 67 | 36 | |||
| Microvascular invasion | |||||
| Yes | 33 | 18 | - | 0.120 | - |
| No | 63 | 30 | |||
| Resection margin | |||||
| (–) | 31 | 33 | 1.768 | 0.011 | 0.178 |
| (+) | 65 | 21 | |||
| Length of negative margin (mm) | |||||
| ≥ 5 | 22 | 33 | - | 0.234 | - |
| < 5 | 43 | 30 | |||
| Proximal margin status | |||||
| (+) | 20 | 19 | 2.688 (1.311-5.510) | 0.002 | 0.007 |
| (–) | 65 | 33 | |||
| LN metastasis | |||||
| Yes | 40 | 15 | 3.293 (1.686-6.434) | < 0.001 | < 0.001 |
| No | 56 | 32 | |||
| Stage (UICC 7th) | |||||
| I/II/III | 33/62/2 | 33/26/24 | 0.128 | - | |
| Adjuvant therapy | |||||
| Yes | 67 | 33 | 1.25 | 0.011 | 0.264 |
| No | 29 | 21 |
HR, hazard ratio; CI, confidence interval; CA 19-9, carbohydrate antigen 19-9; LN, lymph node; UICC International Union Against Cancer.