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Curcumin analogues exhibit potent growth inhibiting effect in cultured esophageal squamous cell carcinoma (ESCC) cells. In vitro MTT cell proliferation assay was performed in three ESCC cell lines SLMT-1, HKESC-2, and KYSE-270 after treatment with curcumin (0-20 μM) and its analogues (0-5 μM). Based on the IC50 obtained after a 48-hour treatment period, curcumin analogues demonstrated more potent growth inhibiting effect in ESCC cells than curcumin. Representative results are shown.
