Table 2.
Univariate and multivariate analyses of risk factors affecting the recurrence of primary uveal melanoma
| Characteristic | No. | Median RFS (95% CI, mo) | p-value | Univariate analysis |
Multivariate analysis |
||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | ||||
| Age, median (range, yr) | |||||||||
| < 30 | 17 | 163.0 (N/A) | 0.929 | 1 | |||||
| 30-60 | 141 | Not reached | 0.83 | 0.324-2.140 | 0.703 | - | - | - | |
| > 60 | 68 | Not reached | 0.85 | 0.293-2.467 | 0.765 | - | - | - | |
| Sex | |||||||||
| Male | 109 | Not reached | 0.062 | 1.71 | 0.965-3.043 | 0.066 | - | - | - |
| Female | 117 | 163.0 (N/A) | 1 | ||||||
| Location | |||||||||
| Choroid | 220 | 163.0 (N/A) | 0.452 | 1 | |||||
| Ciliary body | 6 | 88.0 (N/A) | 1.71 | 0.414-7.048 | 0.459 | - | - | - | |
| Size | |||||||||
| Largest basal diameter (mm) (n=223) | |||||||||
| < 15 | 201 | 163.0 (N/A) | < 0.001 | 1 | 1 | ||||
| ≥ 15 | 22 | 25.0 (0.00-61.18) | 4.73 | 2.326-9.598 | < 0.001 | 2.75 | 1.092-6.904 | 0.032 | |
| Depth (mm) (n=224) | |||||||||
| < 10 | 193 | 163.0 (N/A) | < 0.001 | 1 | 1 | ||||
| ≥ 10 | 31 | 54.0 (N/A) | 3.37 | 1.804-6.308 | < 0.001 | 3.07 | 1.266-7.468 | 0.013 | |
| Stage (n=104) | |||||||||
| I | 26 | Not reached | 0.012 | 1 | |||||
| II | 66 | 82.0 (48.40-115.60) | 8.44 | 1.134-62.787 | 0.037 | - | - | - | |
| III | 12 | 25.0 (N/A) | 15.04 | 1.752-129.043 | 0.013 | - | - | - | |
| Total | 226 | 163.0 (N/A) | |||||||
RFS, recurrence-free survival (time from the initial diagnosis of uveal melanoma to distant recurrence); CI, confidence interval; HR, hazard ratio; N/A, not available.