Table 2.
Univariate and multivariate analysis of recurrence-free survival in 368 patients with resected tracheobronchial adenoid cystic carcinoma
| Variable | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age (yr) | ||||||
| < 50 | 1.00 | 0.435 | ||||
| ≥ 50 | 1.18 | 0.74-1.55 | ||||
| Sex | ||||||
| Male | 1.00 | 0.746 | ||||
| Female | 0.97 | 0.75-1.24 | ||||
| Tracheobronchial location | ||||||
| Trachea | 1.00 | 0.722 | ||||
| Bronchus | 0.96 | 0.61-1.53 | ||||
| Lymph node involvement | ||||||
| Negative | 1.00 | 0.062 | ||||
| Positive | 1.09 | 0.89-1.45 | ||||
| Tumor size (cm) | ||||||
| < 3 | 1.00 | 0.013 | 1.00 | 0.118 | ||
| ≥ 3 | 1.67 | 1.44-1.88 | 1.18 | 0.97-1.43 | ||
| Margin status | ||||||
| Negative | 1.00 | 0.003 | 1.00 | 0.007 | ||
| Positive | 2.35 | 1.91-2.65 | 1.90 | 1.63-2.21 | ||
| Histologic subtype | ||||||
| Cribriform/Tubular | 1.00 | 0.001 | 1.00 | 0.008 | ||
| Solid | 2.36 | 1.63-2.99 | 1.92 | 1.70-2.13 | ||
| Postoperative therapy | ||||||
| Yes | 1.00 | 0.003 | 1.00 | 0.010 | ||
| No | 2.02 | 1.52-2.78 | 1.83 | 1.47-2.19 | ||
| Notch1 expression | ||||||
| Low | 1.00 | 0.009 | 1.00 | 0.032 | ||
| High | 1.90 | 1.68-2.25 | 1.39 | 1.16-1.76 | ||
| FABP7 expression | ||||||
| Low | 1.00 | 0.040 | 1.00 | 0.048 | ||
| High | 1.37 | 1.11-1.63 | 1.34 | 1.11-1.62 | ||
| Notch1/FABP7 expression | ||||||
| Notch1lowFABP7low | 1.00 | 0.010 | 1.00 | 0.036 | ||
| Notch1highFABP7low | 1.15 | 0.67-1.55 | 1.08 | 0.66-1.56 | ||
| Notch1lowFABP7high | 1.28 | 0.96-1.74 | 1.19 | 0.67-1.89 | ||
| Notch1highFABP7high | 1.85 | 1.28-2.62 | 1.37 | 1.12-1.89 | ||
HR, hazard ratio; CI, confidence interval.