Table 3.
Univariate and multivariate analysis of overall survival in 368 patients with resected tracheobronchial adenoid cystic carcinoma
| Variable | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age (yr) | ||||||
| < 50 | 1.00 | 0.440 | ||||
| ≥ 50 | 1.22 | 0.74-1.56 | ||||
| Sex | ||||||
| Male | 1.00 | 0.638 | ||||
| Female | 0.95 | 0.73-1.18 | ||||
| Tracheobronchial location | ||||||
| Trachea | 1.00 | 0.431 | ||||
| Bronchus | 0.92 | 0.71-1.60 | ||||
| Lymph node involvement | ||||||
| Negative | 1.00 | 0.591 | ||||
| Positive | 1.16 | 0.99-1.29 | ||||
| Tumor size (cm) | ||||||
| < 3 | 1.00 | 0.323 | ||||
| ≥ 3 | 1.29 | 0.83-1.79 | ||||
| Margin status | ||||||
| Negative | 1.00 | 0.007 | 1.00 | 0.026 | ||
| Positive | 1.91 | 1.70-2.19 | 1.52 | 1.32-1.79 | ||
| Histologic subtype | ||||||
| Cribriform/Tubular | 1.00 | 0.002 | 1.00 | 0.023 | ||
| Solid | 2.38 | 1.92-2.82 | 1.45 | 1.18-1.97 | ||
| Postoperative therapy | ||||||
| Yes | 1.00 | 0.005 | 1.00 | 0.021 | ||
| No | 2.15 | 1.87-2.45 | 1.66 | 1.37-1.93 | ||
| Notch1 expression | ||||||
| Low | 1.00 | 0.010 | 1.00 | 0.018 | ||
| High | 1.67 | 1.38-2.12 | 1.59 | 1.27-1.90 | ||
| FABP7 expression | ||||||
| Low | 1.00 | 0.167 | 1.00 | 0.375 | ||
| High | 1.10 | 0.93-1.37 | 1.16 | 0.83-1.48 | ||
| Notch1/FABP7 expression | ||||||
| Notch1lowFABP7low | 1.00 | 0.048 | 1.00 | 0.164 | ||
| Notch1highFABP7low | 1.16 | 0.88-1.63 | 1.07 | 0.67-1.58 | ||
| Notch1lowFABP7high | 1.22 | 0.86-1.79 | 1.13 | 0.85-1.71 | ||
| Notch1highFABP7high | 1.47 | 1.15-1.94 | 1.32 | 1.09-2.15 | ||
HR, hazard ratio; CI, confidence interval.