Table 2.
Most common adverse events (Common Terminology Criteria for Adverse Events ver. 4.0)
| Adverse event | All grades | Grade 3-4 |
|---|---|---|
| Hematological | ||
| Anemia | 68 (27.2) | 9 (3.6) |
| Leukopenia | 39 (15.6) | 10 (4.0) |
| Lymphopenia | 30 (12.0) | 11 (4.4) |
| Neutropenia | 107 (42.8) | 93 (37.2) |
| Febrile neutropenia | 14 (5.6) | 12 (4.8) |
| Non-hematological | ||
| Constipation | 51 (20.4) | 1 (0.4) |
| Diarrhoea | 36 (14.4) | 3 (1.2) |
| Nausea | 62 (24.8) | 3 (1.2) |
| Vomiting | 26 (10.4) | 1 (0.4) |
| Asthenia | 141 (56.4) | 20 (8.0) |
| Pyrexia | 56 (22.4) | 2 (0.8) |
| Myalgia | 28 (11.2) | 1 (0.4) |
| Peripheral neuropathy | 58 (23.2) | 12 (4.8) |
| Paresthesia | 44 (17.6) | 2 (0.8) |
| Alopecia | 87 (34.8) | 10 (4.0) |
| Gamma-glutamyltransferase increase | 19 (7.6) | 6 (2.4) |
Values are presented as number (%). Only adverse events related to treatment and with an incidence ≥ 10% for all grades or ≥ 2% for grade 3-4 are presented.