Overall survival (OS) comparison between pancreatic cancer with or without accompanying malignancies from other organs. (A) The OS for pancreatic cancer patients with synchronous or metachronous malignant tumors from other organs was significantly longer than patients with pancreatic cancer only (median, 23.1 months vs. 17.0 months; estimated 5-year survival rate, 27.7% vs. 14.4%; p=0.002). (B) Patients who were diagnosed with pancreatic cancer earlier than other malignancies had better OS (median, 48.9 months) than those with pancreatic cancer only (median, 17.0 months), pancreatic cancers with synchronous other malignant tumors (median, 19.1 months) or pancreatic cancer after other malignancies (median, 13.5 months; OS comparison, p=0.001; 1 vs. 2, p=0.001; 2 vs. 3, p=0.043; 2 vs. 4, p=0.001; 1 vs. 3, p=0.077; 1 vs. 4, p=0.859; 3 vs. 4, p=0.149).