Table 4.
Cumulative adverse events during treatment by maximum grade per patient during treatment
| Adverse event | Toxic effect |
p-valuea) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC+CCRT (n=43) |
CCRT (n=62) |
All grades | Grade 3-4 | |||||||||
| All grades | 1 | 2 | 3 | 4 | All grades | 1 | 2 | 3 | 4 | |||
| Leucopenia | 39 (90.7) | 8 | 19 | 12 | 0 | 40 (93.0) | 18 | 16 | 6 | 0 | 1 | 0.112 |
| Neutropenia | 36 (83.7) | 7 | 15 | 12 | 2 | 22 (51.2) | 11 | 8 | 3 | 0 | 0.001 | 0.003 |
| Anemia | 32 (74.4) | 21 | 8 | 2 | 1 | 17 (39.5) | 12 | 4 | 1 | 0 | 0.001 | 0.609 |
| Thrombocytopenia | 12 (27.9) | 8 | 4 | 0 | 0 | 9 (20.9) | 6 | 3 | 0 | 0 | 0.451 | - |
| AST increased | 8 (18.6) | 8 | 0 | 0 | 0 | 2 (4.7) | 2 | 0 | 0 | 0 | 0.044 | - |
| ALT increased | 21 (48.8) | 18 | 3 | 0 | 0 | 8 (18.6) | 8 | 0 | 0 | 0 | 0.003 | - |
| BUN | 5 (11.6) | 5 | 0 | 0 | 0 | 1 (2.3) | 1 | 0 | 0 | 0 | 0.204 | - |
| CRE | 4 (9.3) | 4 | 0 | 0 | 0 | 1 (2.3) | 1 | 0 | 0 | 0 | 0.357 | - |
| Mucositis | 38 (88.4) | 14 | 17 | 7 | 0 | 42 (97.7) | 13 | 23 | 6 | 0 | 0.204 | 0.763 |
| Dermatitis | 33 (76.7) | 25 | 7 | 1 | 0 | 34 (79.1) | 24 | 9 | 1 | 0 | 0.795 | > 0.999 |
| Vomiting | 28 (65.1) | 17 | 9 | 2 | 0 | 32 (74.4) | 21 | 9 | 2 | 0 | 0.348 | > 0.999 |
Values are presented as number (%). IC, induction chemotherapy; CCRT, concurrent chemoradiotherapy; AST, aspartate amino transferase; ALT, alanine amino transferase; BUN, blood urea nitrogen; CRE, creatinine.
a)
p-values were calculated using a chi-square test (or Fisher exact test).