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. 2018 Oct 17;8:15310. doi: 10.1038/s41598-018-33727-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment with QV formulation increases the number of pancreatic islets and reduces tissue architecture damage. (a–d) Histological sections of the pancreas of experimental animals stained by H&E in 440x magnification. (a–d) Normal architecture of pancreatic islets in groups. Arrows shows the pancreatic islets. (e) Number of pancreatic islets (p = 0.0002). a: C vs D (p = 0.0003); b: C vs DI (p = 0.0020); c: D vs DQV (p = 0.0289). (f) Pancreatic MMP-2 activity. a: C vs D (p = 0.0323); b: D vs DQV (p = 0.0447); c: D vs DI (p = 0.0379). C, control group (n = 5); D, diabetic group (n = 8); DQV, diabetic group treated with QV formulation (n = 6); DI, diabetic group treated with insulin (n = 7). Results expressed as mean ± standard error.