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. 2018 Oct 17;8:15304. doi: 10.1038/s41598-018-33601-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genomic Correlates of HORMAD1 Expression in the TCGA Lung Adenocarcinoma (LUAD) dataset. (a) Boxplot of normalized HORMAD1 RNA expression in tumor and tumor-adjacent normal tissue samples in the LUAD samples. (b,c) Correlation between RNA expression and genomic copy number variation across all expressed. genes in LUAD and breast cancer samples respectively. HORMAD1 is indicated in green, other known HR genes are indicated in red, and NHEJ genes are indicated in blue. (d) Boxplot of genomic copy number variations by high vs low HORMAD1 expression. (e) Barplot of deletion frequency and length by high vs low HORMAD1 expression. (f) Heatmap of correlations between HORMAD1 and gene signature scores across DNA repair pathway gene set. (g) Plot showing correlation of HORMAD1 RNA expression and other CTAs in the LUAD dataset, showing no significant correlation between their expressions. (h) Kaplan-Meier plot of LUAD patients stratified by HORMAD1 expression.