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. 2018 Oct 17;8:15312. doi: 10.1038/s41598-018-33478-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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General patterns of gene expression variation. (A) Normalized log₂(RPKM) expression measurements for all genes projected onto the axes of the first two principal components. Color indicates cell or tissue type. Shape represents species. PC1 and PC2 are both strongly associated with cell or tissue type. (B) Heat map of the pairwise Pearson’s correlation matrix of normalized log₂(RPKM) gene expression values from 13,878 orthologous genes.