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. 2018 Oct 17;8:15331. doi: 10.1038/s41598-018-32853-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Imatinib reduces adipose tissue inflammation and increases insulin sensitivity over time. (a) Fold change gene expression of macrophage markers (CD68, F4/80) and pro-inflammatory M1-markers (TNFα, IL-6) in whole adipose tissue of chow, HFD and HFD + IM-treated animals (n = 5–7). (b) Body weight, insulin sensitivity and glucose tolerance with insulin in diabetic mice treated for one month with imatinib (HFD + STZ + IM) and controls (HFD + STZ; n = 4–5). (c) Body weight, insulin sensitivity and glucose tolerance with insulin in obese mice treated for three months with imatinib (HFD + IM) and controls (HFD; n = 5–6). HFD: High fat diet, IM: imatinib, mos: months, SAC: sacrifice, STZ: Streptozocin. Data expressed as mean ± SEM, *p < 0.05, **p < 0.01.