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. 2018 Oct 17;8:15331. doi: 10.1038/s41598-018-32853-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SREBP target genes are downregulated upon imatinib treatment, while PPARγ-phosphorylation seems to be a secondary phenomenon. (a) Fold change gene expression of SREBP target genes in M1-stimulated peritoneal macrophages treated with or without imatinib (IM) in vitro (n = 9). (b,c) Fold change gene expression of SREBP target genes in peritoneal cells after one and three months of imatinib treatment (n = 4–7). (d,e) Fold change gene expression of SREBP target genes in whole liver tissue after one and three months of imatinib (n = 5–9). (f) Fold change gene expression of PPARγ-phosphorylation-regulated genes in obese mice treated with imatinib (HFD + IM) compared with water-treated controls (HFD) after one (left) and three months of imatinib treatment (right; n = 5–10). AT: adipose tissue, HFD: High fat diet, IM: imatinib, mos: months, PC: peritoneal cells, PM: peritoneal macrophages. Data expressed as mean ± SEM, *p < 0.05, **p < 0.01, ***p < 0.001.