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. 2018 Oct 17;8:15318. doi: 10.1038/s41598-018-33602-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Displays the time-frequency spectrogram associated with the clutter filtered Doppler ensemble, prior to PD computation. Each time-frequency spectrum was calculate at a single-pixel spatial location, indicated in zoomed inset (b), obtained from the PD image (a). Specifically, figures (c–e) and (f–h) corresponds to the green ‘+’ and blue ‘x’ in (b), respectively. The time-frequency spectrums displayed in (c,f) and (d,g) were obtained without motion correction. Data displayed in (c,d) corresponded to the locations indicated by the left and right green ‘+’ in (b), respectively, prior to motion correction. Similarly, the data displayed in (f,g) corresponded to the locations indicated by the left and right blue ‘x’ in (b), respectively, prior to motion correction. Each of the green ‘+’ and blue ‘x’ pixel pairs were separated by 4 pixels. The time-frequency spectrums for the motion corrected data were displayed in (e,h), obtained from the location indicated by the right ‘+’, ‘x’ markers in (b), respectively.