. 2018 Oct 17;8:15329. doi: 10.1038/s41598-018-33587-5

Table 1.

Effect of 11 cidal SMs against biofilm embedded and intracellular APEC bacteria.

	MBEC^† (µM)	SMs intracellular APEC clearance concentration^†† (µM)
		O78			O2			O1
		Caco-2	HD11	THP-1	Caco-2	HD11	THP-1	Caco-2	HD11	THP-1
SM1	400^d	200^a	200^a	200^a	>400	200^a	200^a	>400	400^b	400^b
SM2	50^b	100^a	100^a	100^a	>200	200^b	100^a	>200	200b	200^b
SM3	50^b	100^a	100^a	100^a	>200	200^b	100^a	>200	200^b	200^b
SM4	25^a	50^b	50^b	50^b	100^c	50^b	100^c	100^c	50^b	>100
SM5	25^c	50^c	50^c	50^c	100^d	50^c	50^c	100^d	100^d	100^d
SM6	12.5^a	50^c	50^c	50^c	100^d	50^c	50^c	100^d	100^d	100^d
SM7	50^b	100^c	50^b	50^b	100^c	100^c	25^a	100^c	100^c	>100
SM8	>100	50^c	50^c	50^c	50^c	50^c	50^c	50^c	50^c	50^c
SM9	50^b	50^b	100^c	50^b	100^c	100^c	50^b	100^c	100^c	50^b
SM10	>200	100^c	50^b	100^c	100^c	100^c	50^b	100^c	>100	>100
SM11	400^d	100^a	100^a	100^a	200^b	200^b	100^a	>200	200^b	>200

^†SMs MBEC; ^a0.5X MIC, ^b1X MIC, ^c2X MIC, ^d4X MIC. ^††SMs intracellular APEC clearance concentration; ^a1X MIC, ^b2X MIC, ^c4X MIC, ^d>4XMIC. SMs MBEC and intracellular APEC clearance concentration with “>” arrow indicates SMs not able to eradicate completely the biofilm embedded APEC bacteria or SMs not able to completely clear intracellular APEC up to the concentrations tested.