Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 17;6:30. doi: 10.1038/s41413-018-0031-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — Activated hedgehog signalling promotes the healing of calvarial injuries in Gli1-Cre^ERT2;Bmpr1a^fl/fl mice. a Schematic diagram depicts the experimental design. Calvarial injuries were created in Gli1-Cre^ERT2;tdTomato or Bmpr1a^fl/fl (control) and Gli1-Cre^ERT2;Bmpr1a^fl/fl (mutant) mice 1 day post induction (1dpt) with tamoxifen (TMX). The red boxes indicate the injury. A hedgehog agonist (SAG) was then injected twice a week into one group of mutant mice, starting at the time of injury (rescue). Skulls were analysed 4 weeks post surgery (4wps) to assess healing. b MicroCT analysis of the skull defects in Gli1-Cre^ERT2;tdTomato (control), Gli1-Cre^ERT2;Bmpr1a^fl/fl (mutant), and Gli-Cre^ERT2;Bmpr1a^fl/fl mice treated with SAG (rescue) at 4wps. The inset shows tdTomato visualisation of the boxed region from a Gli1-Cre^ERT2;tdTomato mouse skull. c Quantitation of the percentage of the skull injury defect healed after 4 weeks in five independent samples. ANOVA was performed. **P < 0.01. Scale bars, 1 mm