Table 1.
Known AMR genes uncovered by machine learning
| Antibiotics | Known AMR genes |
|---|---|
| Isoniazid | katG43, inhAa20, fabG144 |
| Rifampicin | rpoB45, rpoCa46 Rv3239c47 |
| Ethambutol | embB48, embC17, ubiAa6, embRa17 |
| Pyrazinamide | pncA 49 |
| Streptomycin | rpsL50, gidB51 |
| Ofloxacin | gyrA 52 |
| 4-Aminosalicylic acid | folCa7, thyAa53 |
| Ethionamide | ethA54, inhAa20 |
| Known AMR genes associated with other antibiotics | dprE155, ald5, alr56, murA57, pks258, pks1259, ppsA60, ppsD60, drrB61, drrC61, moeW55, Rv068762, mshD63, gyrB52, Rv187764, Rv019465 |
The eight antibiotics shown each have an AUC greater than 0.80 (Supplementary Fig. 5)
aNot found in top 40 ranked alleles determined by mutual information, chi-squared, and ANOVA F-test