Fig. 1. Increased lung apoptosis following targeted type II alveolar epithelial cell injury.

a Transgenic SPC-DTR mice treated with daily doses of diphtheria toxin (DT, 10 µg/kg i.p.) for 14 days have increased levels of active caspase 3/7 compared to WT mice. N = 4, p < 0.01. b Two days after daily doses of diphtheria toxin (DT, 10 µg/kg i.p.) bronchoalveolar lavage cells were stained H&E (100x). A subset of alveolar macrophages contain apoptotic bodies (arrowhead)