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. 2018 Oct 11;9:2365. doi: 10.3389/fimmu.2018.02365

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Copyright © 2018 Arevalo-Martin, Grassner, Garcia-Ovejero, Paniagua-Torija, Barroso-Garcia, Arandilla, Mach, Turrero, Vargas, Alcobendas, Rosell, Alcaraz, Ceruelo, Casado, Talavera, Palazón, Sanchez-Blanco, Maier, Esclarin and Molina-Holgado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autoantibody levels are higher in spinal cord injury patients independently of lesion level and severity. (A,B) IgG and IgM AAb binding are not significantly different after performing t-test (p-value in y-axis) followed by false discovery rate (FDR) correction between tetraplegic and paraplegic patients, but for a single IgM AAb against HBA (orange-filled spot, B). (C,D) However, when classifying patients into those with lesions above or below T5 spinal segment, not a single AAb present different levels between the two groups. (E,F) Complete patients (AIS A) and incomplete patients (AIS B–D) do not show significant differences in IgG nor IgM AAb levels. (G,H) Comparison of cervical AIS D central cord syndrome patients (CCS, a less severe traumatic spinal cord injury) with their counterparts cervical AIS A patients (Non-CCS) also fails to found any statistically significant difference in AAb levels due to lesion severity. Dotted horizontal orange line represents t-test p-value = 0.05. Orange-filled spot represents FDR < 0.05 after multiple comparison correction by Benjamini-Yekutieli method.