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. 2018 Oct 11;9:2365. doi: 10.3389/fimmu.2018.02365

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Copyright © 2018 Arevalo-Martin, Grassner, Garcia-Ovejero, Paniagua-Torija, Barroso-Garcia, Arandilla, Mach, Turrero, Vargas, Alcobendas, Rosell, Alcaraz, Ceruelo, Casado, Talavera, Palazón, Sanchez-Blanco, Maier, Esclarin and Molina-Holgado.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of autoantibody targets reveals functions that could be affected by AAbs or that are affected by other injury-related processes and are being sensed by AAbs. Biological Function Gene Ontology terms associated to AAb targets are functionally organized into a network structure. Only significant terms after hypergeometric test followed by Benjamini-Hochberg multiple comparison correction are shown. Most significant terms of each functional group are highlighted. Six functional clusters may be established (A–E): (A) a cluster formed by terms coupled to intermediate filaments-related functions, including proliferation and autophagy; (B) a cluster related to the control of oxygen radicals and oxygen transport, that is functionally related to a subcluster comprising CAH2 (carbonic anhydrase 2) functions, including bone remodeling; (C) a cluster including terms related to energetic metabolism, comprising glycolysis and NAD and ATP biosynthesis; (D) functions related to albumin; (E) functions related to PPIA (also known as cyclophilin A) that are involved in control of viral latency; (F) glutamate biosynthesis.