Table 3.

Cortical mean diffusivity changes over 1 year of follow-up in PwCIS.

Regions	Baseline MD (10−3 mm2/s)	1-year MD (10−3 mm2/s)
Frontal_L	1.05 ± 0.13	1.11 ± 0.16**
Cingulate_L	0.93 ± 0.10	0.98 ± 0.11**
Occipital_L	0.89 ± 0.06	0.90 ± 0.07
Temporal_L	0.90 ± 0.05	0.92 ± 0.06**
Parietal_L	0.95 ± 0.11	1.01 ± 0.12***
Insula_L	1.03 ± 0.08	1.04 ± 0.10
Frontal_R	1.05 ± 0.12	1.11 ± 0.14
Cingulate_R	0.96 ± 0.09	0.99 ± 0.11
Occipital_R	0.90 ± 0.07	0.92 ± 0.07
Temporal_R	0.91 ± 0.06	0.92 ± 0.06
Parietal_R	0.96 ± 0.11	1.02 ± 0.13**
Insula_R	1.02 ± 0.08	1.03 ± 0.10

MD, Mean diffusivity. L, Left hemisphere; R, Right hemisphere. p-values indicate significant differences after multiple comparisons correction.

^**p < 0.01;

^***p < 0.001.