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. 2018 Oct 11;9:828. doi: 10.3389/fneur.2018.00828

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Copyright © 2018 Tahedl, Levine, Greenlee, Weissert and Schwarzbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The relationship between MS symptoms and brain networks. Conceptual depiction of the often-reported match between the affected network and the specific symptom class from which patients suffer, as discussed in the section “What can functional connectivity (FC) tell us about symptom severity?” For example, the default-mode network (DMN, red) is associated with cognitive performance, and the sensorimotor network (SMN, blue) is associated with motor performance. MS patients with deficits in cognitive performance often have reduced FC within the DMN and increased FC within the SMN (as compared to patients without such deficits). The analog pattern of intra-domain decrease and extra-domain increase is observed for patients with deficits in motor performance, with respect to the SMN and DMN, respectively (as compared to patients without such deficits).