FIGURE 3.

SeCl₄ inhibited sleep in LPGDS^flox control mice (CTRL), CP-LPGDS KO mice, and OD-LPGDS KO mice, but not in LM-LPGDS KO mice. (A) Typical examples of EEG, EMG, and locomotor activity (LMA), and hypnograms after administration of saline (vehicle) or SeCl₄ in LPGDS^flox control and LM-LPGDS KO mice. (B) Injection of SeCl₄ significantly (decreased the hourly amount of sleep during the subsequent 3 h compared with saline in LPGDS^flox control mice, CP-LPGDS KO mice, and OD-LPGDS KO mice, but not in LM-LPGDS KO mice. (C) Injection of SeCl₄ dramatically decreased the total amount of sleep during the subsequent 4 h compared with saline in LPGDS^flox control mice, CP-LPGDS KO mice, and OD-LPGDS KO mice, but not in LM-LPGDS KO mice. Values are means ± SEM (n = 6–8). ^∗∗P < 0.01 compared with its own control (saline).)