Fig. 3.

Recovery with UDCA treatment. (A) Fibroblasts are treated for 24 h with 100 nM UDCA. UDCA treatment, however, increases mitochondrial membrane potential. The increase from the untreated state for controls, sporadics and familial cell lines varies between 0 and 5% for controls, 12% and 28% for sAD and 19% and 21% for PSEN1 (*p < 0.05). (B) The increase in mitochondrial membrane potential when fibroblasts are treated with 100 nM of UDCA. The relative increase from the untreated state for controls, sporadics and familial cell lines is 0%, 11% and 25%, respectively (*p < 0.05). Each measurement was repeated on three separate passages of each cell line.