Figure 1.

Design, preparation, and characterization of a ROS‐scavenging material. a) Schematic illustration of engineering of a broad spectrum ROS‐scavenging material and nanoparticle based on functionalized β‐cyclodextrin (β‐CD). b) The synthetic route of β‐CD conjugated with Tempol (Tpl) and PBAP units (TPCD). CDI, 1,1‐carbonyldiimidazole; DMAP, 4‐dimethylaminopyridine; TCD, Tpl‐conjugated β‐CD; PBAP, 4‐(hydroxymethyl) phenylboronic acid pinacol ester. c) ¹H NMR spectra of different materials including β‐CD, TCD, and TPCD. The character “s” denotes the presence of trace amount of solvent impurities, such as DMSO and DMAP residuals from the precipitation process. d) UV–visible absorption spectra of different compounds. e) EPR spectra of free Tpl, TCD, and TPCD. f) A ¹H NMR spectrum of the hydrolyzed TPCD sample in D₂O. HMP, p‐(hydroxymethyl)phenol. g) The mechanism for the H₂O₂‐mediated hydrolysis of TPCD.