Figure 6.

MXene‐based synergistic multitherapies. a) Schematic illustration of surface modification of Ti₃C₂ MXene, further surface engineering of drug loading, and stimuli‐triggered drug releasing under inner and external triggers. b) In vivo process of Ti₃C₂ MXene‐based drug delivery system (DDS) for synergistic photo‐chemotherapy of tumor. c) The DOX‐releasing curves from DOX@Ti₃C₂ composite nanosheets in buffer with varied pHs of 4.5, 6.0, and 7.4. d) The DOX‐releasing curves with 808 nm laser irradiation on or off at varied pH values (4.5, 6.0, and 7.4). e) CLSM images of cancer cells after various treatments, including control, laser, DOX, DOX@Ti₃C₂‐SP, Ti₃C₂‐SP + laser, and DOX@ Ti₃C₂‐SP + laser groups. Scale bar: 50 µm. f) Time‐dependent tumor growth profiles after different treatments. Reproduced with permission.104 Copyright 2018, Wiley‐VCH. g) Schematic diagram of the construction of Ti₃C₂‐based nanosystem and photothermal/photodynamic/chemo synergistic therapy of tumor. h) Accumulative drug release curves with or without NIR laser irradiation at pH 4.5, 6.0, and 7.4. i) CLSM images of HCT‐116 cells treated with Ti₃C₂‐DOX (top), and DCFH‐DA‐stained HCT‐116 cells treated with Ti₃C₂‐DOX under NIR laser irradiation for the intracellular ROS detection (bottom). Reproduced with permission.52 Copyright 2017, American Chemical Society.