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. 2018 Oct 11;10:292. doi: 10.3389/fnagi.2018.00292

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Copyright © 2018 Morin, Mouzon, Ferguson, Paris, Saltiel, Lungmus, Mullan and Crawford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the effect of Nilvadipine after r-mTBI on microglial population (Iba1) at 22 days post-r-mTBI in CC, CA1 and cortex: (A–D) Representative images (20×) of the Iba1 staining in the CC revealed increased microglial activation after r-mTBI (p < 0.0001) and a reduction of Iba1 immunoreactivity by Nilvadipine (p < 0.001). No difference in Iba1 was detected for CA1 (A–D) and cortex (E–H). Quantitative analysis of Iba1 staining in three 100 μm² fields of the CC (I), CA1 (J) and cortex (K) at 22 days post-injury confirms the injury-induced and Nilvadipine-induced changes in glial response in CC. Scale bars equal 50 μm. Data are presented as mean ± standard error of the mean; significance is calculated using one-way ANOVA. ***p < 0.001; ****p < 0.0001.