Fig. 3.

Dose–response profile of midazolam on seizure activity and survival in the DFP model in rats. (A) Sigmoid plot of midazolam protection against DFP-induced seizures. Midazolam (0.2–5 mg/kg, i.m.) was given 40 minutes after DFP exposure. Responders were determined by termination or reduction of seizure activity within 60 minutes after drug injection. (B) Mortality rate in midazolam-treated groups at 24 and 48 hours after DFP exposure. Each point represents the group incidence data (n = 8–15 rats per group). *P < 0.05 versus DFP alone (green dot) group (Wilcoxon signed-rank test).