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. 2018 Oct 17;19:163. doi: 10.1186/s13059-018-1553-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — The characterization of small RNAs transcriptome by Holo-Seq. a Number of miRNAs, tsRNAs and snoRNAs detected in mESC single cells. b Size distribution of miRNAs profiled from mESC single cells. Error bars indicate the Standard Deviation (SD). c Heat map of the relative expression levels of miRNAs, tsRNAs and snoRNAs profiled from 13 mESC single cells. d Pearson correlation heat maps of miRNAs, tsRNAs, and snoRNAs abundance profiled from ZHBTc4 cells (bulk small-RNA-Seq) and 1 ng ZHBTc4 total RNAs (Holo-Seq)