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. 2018 Oct 11;9:1423. doi: 10.3389/fphys.2018.01423

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Copyright © 2018 Alcalá-Corona, Espinal-Enríquez, de Anda-Jáuregui and Hernández-Lemus.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hierarchical levels of modularity in the HER2+ network. In each panel, the giant component of the HER2+ breast cancer network is depicted. The colors of the nodes in each panel represent different groupings: (A) all nodes are colored the same, as they belong to the same connected component. (B) Nodes are colored by expression levels (blue: underexpressed, red: overexpressed) regardless of connectivity patterns. Notice that genes are grouped together depending on the differential expression pattern. (C) Nodes are colored according to modules detected by Infomap; in (D) nodes are colored by submodules inside the modules, these submodules were detected using the hierarchical map equation.