. Author manuscript; available in PMC: 2018 Oct 18.

Published in final edited form as: Chem Biol Interact. 2008 Nov 5;178(1-3):134–137. doi: 10.1016/j.cbi.2008.10.044

Table 2.

Inhibition kinetic parameters for dl-glyceraldehyde reduction activity of Cys299Ser mutant AKR1B10 by various inhibitors.

Compound	Inhibition constant (μM)			Mode of inhibition
	IC₅₀	K_ii	K_is

Ciprofibrate	ND	815	705	mNC
Fenofibrate	10	11	16	mNC
Fenofibric acid	220	250	240	pNC
Gemfibrozil	380	415	370	mNC
Wy 14,346	350	360	240	mNC
Zopolrestat	9	11	12	mNC

mNC–mixed non-competitive; pNC–pure non-competitive; ND–not detectable; EBPC and sorbinil did not show measurable levels of inhibiting Cys299Ser mutant AKR1B10.