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. Author manuscript; available in PMC: 2018 Oct 18.

Published in final edited form as: Eur J Pharmacol. 2008 Feb 5;584(2-3):213–221. doi: 10.1016/j.ejphar.2008.01.036

Table 1.

Inhibition kinetics parameters for DL-glyceraldehyde reduction activity of wildtype AKR1B10 by various inhibitors

Compound	Inhibition constant (μM)				Mode of inhibition
Compound	IC₅₀	K_ii	K_is	Comparison	Mode of inhibition
Zopolrestat	8.0±1.0	10.0±1.0	10.5±1.0	K_ii≈K_is	pNC
EBPC	12.3±0.7	13.5±0.5	13.0±0.5	K_ii≈K_is	pNC
Fenofibrate	25.0±5.0	30.2±3.0	27.5±2.0	K_ii≠K_is	mNC
Wy 14,643	60.0±10.0	60.0±5.0	45.0±5.0	K_ii≠K_is	mNC
Sorbinil	100.0±15	80±10.0	90±10.0	K_ii≈K_is	pNC
Ciprofibrate	210.0±15.0	190.0±10.0	240.0±15.0	K_ii≠K_is	mNC
Fenofibric acid	300.0±30.0	220.0±20.0	250.0±15.0	K_ii≠K_is	mNC

mNC — mixed non-competitive; pNC — pure non-competitive.